Ersin Ogus

Baskent University, Faculty of Medicine, Faculty Member

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Istanbul Education and Research Hospital

Bart Hellebrekers

Tarik Sammour

The University of Adelaide

Emre ERGÜL

Kemal Karakaya

Sanket Srinivasa

The University of Auckland

Otmar Buyne

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Papers by Ersin Ogus

Clinical and radiographic evaluations of chitosan gel in periodontal intraosseous defects: A pilot study

by Sevda Şenel, Ahu Uraz, Ersin Ogus, and Burcu Özdemir

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2009

Periodontitis is a chronic infection in the supportive tissue of the teeth which eventually leads... more Periodontitis is a chronic infection in the supportive tissue of the teeth which eventually leads to tooth loss. Various grafting materials and barrier membranes have been used to repair periodontal intraosseous lesions. Chitosan is a derivative of chitin, a natural biopolymer, which is biologically safe, biodegradable, and nontoxic and has been applied in a variety of forms in dentistry. It also exerts bioactive properties such as wound healing, antimicrobial, tissue regeneration, and hemostatic activities. The aim of this study was to evaluate effects of chitosan on periodontal regeneration. Twenty chronic periodontitis patients were recruited. Following initial therapy, the patients were divided into four groups: group A, receiving chitosan gel (1% w/v); group B, receiving chitosan gel 1 demineralize bone matrix; group C: receiving chitosan gel 1 collagenous membrane; and group D, receiving flap only (control group). Clinical and radiographic measurements were recorded at baseline, day 90 (3rd month), and day 180 (6th month) after surgery. For clinical data, no significant differences were obtained among the treatment groups. However, radiographic data revealed that except control group, all the other groups showed statistically significant bone fills when compared with baseline indicating that chitosan gel alone or its combination with demineralize bone matrix/collagenous membrane is promising for periodontal regeneration. '

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Effect of Er,Cr:YSGG laser irradiation on the apical sealing ability of AH Plus/gutta-percha and Hybrid Root Seal/Resilon Combinations

by Gizem Berk and Ersin Ogus

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2010

Objective. The objective of this study was to evaluate the sealing ability of 2 different resin-b... more Objective. The objective of this study was to evaluate the sealing ability of 2 different resin-based endodontic filling systems after smear layer removal with 2 different techniques. Study design. Extracted human single-rooted teeth (n ϭ 74) were instrumented using HERO Shaper rotary instruments and irrigated with 1 mL of 2.5% NaOCl between each instrument. Additionally, the canals received either an extra 3-minute rinse with 2 mL of 17% EDTA or a 40-second Er,Cr:YSGG laser treatment. The root canals were filled with either Hybrid Root Seal/Resilon combination or AH Plus/gutta-percha combination using lateral condensation technique (n ϭ 11). Apical leakage quantity was measured with the computerized fluid filtration meter at 1 and 4 weeks. One root from each group, which was not submitted to the fluid filtration test, was selected for scanning electron microscopy (SEM) analysis. Statistical analysis was performed using 3-way ANOVA and the post hoc Tukey HSD test (␣ ϭ 0.05). Results. A significant decrease was observed in the microleakage values of all the experimental groups tested with time (P Ͻ .0001). EDTA ϩ AH Plus/gutta-percha combination exhibited the least microleakage, whereas laser irradiation ϩ Hybrid Root Seal/Resilon combination showed the greatest microleakage at each of the 2 time periods. Each experimental combination exhibited architecture in SEM that seemed to correlate with its sealing performance. Conclusion. Er,Cr:YSGG laser treatment does not enhance the sealing ability of the sealers compared with EDTA application. The root canal adaptation and sealing ability of the Hybrid Root Seal/Resilon combination is not superior to that of the AH Plus/gutta-percha combination.

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Two percent chitosan mouthwash: A microbiological and clinical comparative study

by Ahu Uraz, Ersin Ogus, and Nedim Sultan

Journal of Dental Sciences, 2012

ABSTRACT Background/purposeThe aim of this study was to evaluate the microbiological and clinical... more ABSTRACT Background/purposeThe aim of this study was to evaluate the microbiological and clinical effects of a chitosan (CH) mouth rinse on plaque inhibition.Materials and methodsThirty-six healthy participants were recruited. The following clinical data were recorded: a plaque index (PI), gingival index (GI), Quickley–Hein plaque index (QPI), and probing depth (PD). Volunteers were given oral hygiene (OH) instruction and trained on scaling and professional tooth cleaning (PTC). After the final PTC, volunteers were randomly allocated into three groups. Group A rinsed with 2% CH, group B rinsed with 0.2% chlorhexidine digluconate (CHX), and group C rinsed with 2% CH + 0.2% CHX. Plaque samples were collected and assayed for Streptococcus mutans, Candida albicans, and enterococci.ResultsAfter a non-brushing period, the full-mouth PI and QPI values between the CH and CHX + CH groups differed significantly. A higher PI score at sampling sites was seen in the CH group, but no significant differences were observed between groups. The S. mutans and C. albicans levels were statistically significant in each group on Days 0 and 4. Differences of C. albicans levels between groups were found to be significant; however, no statistical differences were obtained for S. mutans or enterococci levels among the groups at the various time intervals.Conclusion We conclude that further investigations are needed to evaluate the potential value of CH as an effective antiplaque mouth rinse.

Oral fluvastatin reduces the severity of peritoneal adhesions in rats

by Z. Karabulut and Ersin Ogus

Acta chirurgica Belgica

The aim of the study was to investigate the effect of fluvastatin on peritoneal adhesion formatio... more The aim of the study was to investigate the effect of fluvastatin on peritoneal adhesion formation. 48 female Wistar-albino rats weighing 200-220 g were divided into four groups each containing 12 rats. Group I was sham, Group II was the control group, while Group III was given 10 mg/kg/day (28 days) oral fluvastatin. In Group IV, 10 mg/kg fluvastatin was administered intraperitoneally at the time of laparotomy but the rats died from that dose. After laparotomy on day 14, caecal serosal abrasions and punctuate haemorrhagies were performed. On day 28, laparotomies were repeated. Adhesions were graded and tissue samples were taken from incisions and adhesions. Hydroxyproline contents representing adhesions were measured quantitatively. On the 28th day, blood samples were taken to measure the tissue-type plasminogen activator (t-PA) activity. There were significant differences between the groups for adhesion severity (p < 0.0001), hydroxyproline content and t-PA activity of the adhe...

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Elevated CK-MB mass and plasma brain-type natriuretic peptide concentrations following convulsive seizures in children and adolescents: Possible evidence of subtle cardiac dysfunction

by Kürşad Tokel and Ersin Ogus

Epilepsia, 2009

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The preventive effects of thiopental and propofol on testicular ischemia-reperfusion injury

by M. Caydere and Ersin Ogus

Acta Anaesthesiologica Scandinavica, 2006

Background: Testicular torsion is a urological emergency that requires immediate surgical interve... more Background: Testicular torsion is a urological emergency that requires immediate surgical intervention to prevent testicular damage. The aim of the study was to investigate the preventive effects of thiopental and propofol as anesthetics on testicular ischemia-reperfusion injury. Methods: Forty male Wistar Albino rats were randomly assigned to four groups of 10 rats each. During 5 h, anesthesia was induced and maintained with thiopental in groups 1 and 2 and with propofol in groups 3 and 4. Groups 2 and 4 received left testicular ischemia (torsion) during 1 h and reperfusion (detorsion) during 4 h. Groups 1 and 3 (control groups) had no testicular torsion and detorsion. At the end of 5 h, animals were killed and both ipsilateral and contralateral testes were removed for histopathologic examination and measurement of tissue MDA (malondialdehyde) and NO (nitric oxide) levels. Results: In the contralateral testes of all the groups, MDA and NO measurements were not different from ipsilateral testes of the control groups. Between the groups 1 and 3, there were no differences in MDA and NO levels. Although torsion/detorsion of testes in group 4 caused significantly increased levels of tissue MDA and NO values compared with group 3, ischemia-reperfusion in group 2 caused a further increase in these levels compared with group 4. The ipsilateral testes in the control groups did not show any morphological changes. Testicular torsion/detorsion in rats with thiopental anesthesia (group 2) caused significantly greater histopathologic injury levels than rats with propofol anesthesia (group 4). Conclusion: Our results suggest that propofol as an anesthetic agent may prevent testicular damage by scavenging reactive oxygen and nitrogen species and inhibiting lipid peroxidation in an animal model of testicular torsion and detorsion.

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Clinical and radiographic evaluations of chitosan gel in periodontal intraosseous defects: A pilot study

by Sevda Şenel, Ahu Uraz, Ersin Ogus, and Burcu Özdemir

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2009

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Effect of Er,Cr:YSGG laser irradiation on the apical sealing ability of AH Plus/gutta-percha and Hybrid Root Seal/Resilon Combinations

by Gizem Berk and Ersin Ogus

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2010

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Two percent chitosan mouthwash: A microbiological and clinical comparative study

by Ahu Uraz, Ersin Ogus, and Nedim Sultan

Journal of Dental Sciences, 2012