Papers by samriti faujdar
Journal of complementary & integrative medicine/Journal of complementary and integrative medicine, Jul 1, 2024
Journal of Traditional and Complementary Medicine, Oct 1, 2017
The present study was carried out to evaluate analgesic and anti-inflammatory activities in stem ... more The present study was carried out to evaluate analgesic and anti-inflammatory activities in stem and root extracts along with heavy metals estimation in stem and root powder. Stem and roots were extracted with chloroform (ICSCE, ICRCE) and methanol (ICSME, ICRME). Acute oral toxicity of all extracts was determined by OECD guidelines 425. Analgesic activity was investigated by using hot plate and acetic acid induced writhing models. Anti-inflammatory activity (acute) of all extracts was evaluated by carrageenan induced paw edema model. In addition, root and stem powder was screened for heavy metals (As, Pb, Cd, Hg) estimation using atomic absorption spectroscopy. In acute toxicity study no mortality was observed when each extract was orally administered with 2.0 g/kg. At the doses (100 and 200 mg/kg) ICRME followed by ICSME showed significant and dose dependent analgesic and anti-inflammatory effects compared with chloroform extracts. The heavy metals concentration in stem and root powders was found to be within the permissible limits as recommended by WHO for herbal raw materials. The findings of the present study validated the folkloric use of as analgesic and anti-inflammatory. In addition, the results intimate that heavy metals present in raw material were found to be within the defined limits, and it exhibits that the therapeutic efficacy of plant may not be effected, which can be otherwise possibly effected if the plant sequester high concentration of heavy metals from the polluted environment as well as from the soil rich in pesticides and sewage sludge etc.
Beni-Suef University Journal of Basic and Applied Sciences, 2016
The aim of the present study was to investigate and compare the analgesic and antiinflammatory ac... more The aim of the present study was to investigate and compare the analgesic and antiinflammatory activities of hydroalcoholic extracts of bark and leaves of Acacia ferruginea DC. Hydroalcoholic extracts of bark and leaves were evaluated for analgesic activity using hot plate method and acetic acid-induced writhing test, whereas the anti-inflammatory activity was evaluated by carrageenan-induced paw oedema method. Hydroalcoholic extract of the bark at the dose of 50 mg/kg (6.10 ± 0.30) and leaves at a dose of 100 mg/kg (5.72 ± 0.39) after 45 min exhibited significant (P < 0.001) analgesic activity in hot plate test, which was comparable to Tramadol (6.11 ± 0.31) at a dose of 10 mg/kg. However, in acetic acidinduced writhing test, hydroalcoholic extract of both bark (90%) and leaves (90.91%) showed maximum protection from acetic acid at the dose of 100 mg/kg as compared to standard drug (50.91%) at a dose of 5 mg/kg. In the evaluation of anti-inflammatory activity, hydroalcoholic extract of leaves at a dose of 400 mg/kg had significantly (74.68%) inhibited the inflammation as comparable to indomethacin (82.8%) after 3 h of induction of carrageenan. It is concluded that hydroalcoholic extracts of bark and leaves have central analgesic and peripheral analgesic effects, respectively. Both hydroalcoholic extracts of the bark and leaves significantly reduced the paw oedema at a dose of 400 mg/kg and exhibited antiinflammatory activity.
Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for cu... more Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for curing different ailments. The aim of the present work is to estimate total phenolic content found in the leaves of Murraya koenigii. Method:- Total phenolic content of Murraya koenigii was assessed by Folin-Ciocalteu reagent by using gallic acid as calibration standard. Result:- The total phenolic content was measured by Folin-Ciocalteu was found to be 5.32. Conclusion:- From the findings it may be concluded that this drug may find use in diabetes and liver related problems.
International Journal of Research and Development in Pharmacy and Life Sciences, 2012
Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for cu... more Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for curing different ailments. The aim of the present work is to estimate total phenolic content found in the leaves of Murraya koenigii. Method:- Total phenolic content of Murraya koenigii was assessed by Folin-Ciocalteu reagent by using gallic acid as calibration standard. Result:- The total phenolic content was measured by Folin-Ciocalteu was found to be 5.32. Conclusion:- From the findings it may be concluded that this drug may find use in diabetes and liver related problems.
In vitro antioxidant activity of methanol extract of Cassia occidentalis seeds was determined by ... more In vitro antioxidant activity of methanol extract of Cassia occidentalis seeds was determined by DPPH free radical scavenging, FRPA, Lipid peroxidation by thiobarbituric acid assay methods. The analysis had shown the maximum percentage inhibition in case of DPPH method as 66.53% at 160μg/ml and 61.07% in lipid peroxidation at 1000μg/ml. Further, reducing power of methanol extract of seeds increased in concentrationdependent manner. Total phenolic content estimation was done by using Folin-Ciocalteu reagent and was found to be 0.75% w/w. The present study revealed that the methanol extract of seeds have antioxidant potential and represent a potential source of medicine.
Journal of Traditional and Complementary Medicine, Apr 1, 2019
ABSTRACT Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medici... more ABSTRACT Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for curing different ailments. The aim of the present work is to estimate total phenolic content found in the leaves of Murraya koenigii. Method:- Total phenolic content of Murraya koenigii was assessed by Folin-Ciocalteu reagent by using gallic acid as calibration standard. Result:- The total phenolic content was measured by Folin-Ciocalteu was found to be 5.32. Conclusion:- From the findings it may be concluded that this drug may find use in diabetes and liver related problems. Keywords: Murraya koenigii, Phenolic content, UV-Visible Spectrophotometer
Journal of traditional and complementary medicine, 2017
The present study was carried out to evaluate analgesic and anti-inflammatory activities in stem ... more The present study was carried out to evaluate analgesic and anti-inflammatory activities in stem and root extracts along with heavy metals estimation in stem and root powder. Stem and roots were extracted with chloroform (ICSCE, ICRCE) and methanol (ICSME, ICRME). Acute oral toxicity of all extracts was determined by OECD guidelines 425. Analgesic activity was investigated by using hot plate and acetic acid induced writhing models. Anti-inflammatory activity (acute) of all extracts was evaluated by carrageenan induced paw edema model. In addition, root and stem powder was screened for heavy metals (As, Pb, Cd, Hg) estimation using atomic absorption spectroscopy. In acute toxicity study no mortality was observed when each extract was orally administered with 2.0 g/kg. At the doses (100 and 200 mg/kg) ICRME followed by ICSME showed significant and dose dependent analgesic and anti-inflammatory effects compared with chloroform extracts. The heavy metals concentration in stem and root p...
Momordica balsamina L. fruit pulp and its extracts were evaluated for antidiabetic potential. The... more Momordica balsamina L. fruit pulp and its extracts were evaluated for antidiabetic potential. The study was carried out on whole fruit pulp powder (FPP), aqueous methanolic extract 90% (AME) and aqueous extract for 3 weeks on streptozotocin (STZ) induced diabetic Wistar rats. The biochemical parameters studied were serum glucose level, lipid profile and liver glycogen content along with this body weight was also measured. The ME showed significant (P<0.05) serum glucose lowering effect, improvement in the complete lipid profile and check on the loss of body weight in comparison to control diabetic rats. The results were comparable with glibenclamide (GLB) 500 µg/kg, standard antidiabetic drug. Phytochemical screening of the AME revealed the presence of alkaloids, flavonoids and steroids. Our findings suggest, the FPP and AME have significant (P<0.05) antidiabetic potential and can act as an effective oral hypoglycemic drug in diabetes.
Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for cu... more Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for curing different ailments. The aim of the present work is to estimate total phenolic content found in the leaves of Murraya koenigii. Method:- Total phenolic content of Murraya koenigii was assessed by Folin-Ciocalteu reagent by using gallic acid as calibration standard. Result:- The total phenolic content was measured by Folin-Ciocalteu was found to be 5.32. Conclusion:- From the findings it may be concluded that this drug may find use in diabetes and liver related problems. Keywords: Murraya koenigii, Phenolic content, UV-Visible Spectrophotometer
International Journal of Pharmaceutical Sciences Review and Research
The plant Momordica balsamina Linn. belongs to family Cucurbitaceae and found in Punjab, Rajastha... more The plant Momordica balsamina Linn. belongs to family Cucurbitaceae and found in Punjab, Rajasthan and Saurashtra. The African people use the fruit of Momordica balsamina Linn. as a medicine for a variety of ailments. Since no reports are available on the pharmacognostical and phytochemical evaluation regarding the fruits of Momordica balsamina Linn., so present study was devoted to study macroscopy, microscopical, physiochemical and phytochemical properties of the fruit. From the study we have found that Immature fruit is green, ovoid, 2.5-7.5 cm long, narrow to both ends, rostrate, fleshy, smooth or muricate and bitter in taste. Mature fruit is red, berry type of fruit and tuberculate in shape. Seeds are ash coloured, ellipsoid, compressed, rugulose on the flat faces and with a grooved margin which is tuberculate on edges. Microscopically, fruits show epidermis with stomata, Uniseriate and multicellular glandular trichomes, hypodermis, prismatic crystals of calcium oxalates, mesoc...
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
Medicinal plants have been known as a rich source of therapeutic agents for the prevention of var... more Medicinal plants have been known as a rich source of therapeutic agents for the prevention of various ailments. It is a common disorder estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males, and 47-60% in females. Herbal drugs finds place in treating kidney stone. Now people motivate towards the herbal drugs due to the side effects associated with synthetic drug. The aim of the present review is to provide details of the plants used in the lithiasis.
This paper represents the pharmacognostic and phytochemical evaluation of leaves of Nerium indicu... more This paper represents the pharmacognostic and phytochemical evaluation of leaves of Nerium indicum commonly known as Kaner, a traditional medicinal plant and used as cardiotonic, diaphoretic, diuretic, emetic, expectorant and antimalarial agent. The present study was undertaken to standardize the Nerium indicum leaves so as to utilize this medicinal plant for optimum efficacy.
In vitro antioxidant activity of methanol extract of Cassia occidentalis seeds was determined by ... more In vitro antioxidant activity of methanol extract of Cassia occidentalis seeds was determined by DPPH free radical scavenging, FRPA, Lipid peroxidation by thiobarbituric acid assay methods. The analysis had shown the maximum percentage inhibition in case of DPPH method as 66.53% at 160µg/ml and 61.07% in lipid peroxidation at 1000µg/ml. Further, reducing power of methanol extract of seeds increased in concentration-dependent manner. Total phenolic content estimation was done by using Folin-Ciocalteu reagent and was found to be 0.75% w/w. The present study revealed that the methanol extract of seeds have antioxidant potential and represent a potential source of medicine.
In vitro antioxidant activity of methanolic and aqueous extracts of fruit pulp of Momordica balsa... more In vitro antioxidant activity of methanolic and aqueous extracts of fruit pulp of Momordica balsamina was assessed by DPPH free radical scavenging, FRPA, Lipid peroxidation by thiobarbituric acid assay methods. The methanol and the aqueous extract had shown DPPH scavenging activity (IC50=371.29±1.57 μg/ml and IC50=384.22±2.46 μg/ml) respectively when compared with the IC50 values of the standards ascorbic acid and rutin (IC50=8.84±0.05 and 3.78±0.153 μg/ml respectively) and IC50 values of methanolic (311.07±0.009 μg/ml) and aqueous (386.01±0.006 μg/ml) extracts in lipid peroxidation as compared to BHT (48.89±0.01 μg/ml) μg/ml. The reducing power of the extracts were found to be concentration dependent. The total phenolic content was measured by Folin-Ciocalteu reagent was found to be 2.34%w/w.
In vitro antioxidant activity of methanolic and aqueous extracts of fruit pulp of Momordica balsa... more In vitro antioxidant activity of methanolic and aqueous extracts of fruit pulp of Momordica balsamina was assessed by DPPH free radical scavenging, FRPA, Lipid peroxidation by thiobarbituric acid assay methods. The methanol and the aqueous extract had shown DPPH scavenging activity (IC50=371.29±1.57 μg/ml and IC50=384.22±2.46 μg/ml) respectively when compared with the IC50 values of the standards ascorbic acid and rutin (IC50=8.84±0.05 and 3.78±0.153 μg/ml respectively) and IC50 values of methanolic (311.07±0.009 μg/ml) and aqueous (386.01±0.006 μg/ml) extracts in lipid peroxidation as compared to BHT (48.89±0.01 μg/ml) μg/ml. The reducing power of the extracts were found to be concentration dependent. The total phenolic content was measured by Folin-Ciocalteu reagent was found to be 2.34%w/w.
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Papers by samriti faujdar