{"id":"https:\/\/openalex.org\/W3128444782","doi":"https:\/\/doi.org\/10.1109\/bibm49941.2020.9313448","title":"DRAMA: Discovering Disease-related circRNA-miRNA-mRNA Axes from Disease-RNA Information Network","display_name":"DRAMA: Discovering Disease-related circRNA-miRNA-mRNA Axes from Disease-RNA Information Network","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https:\/\/openalex.org\/W3128444782","doi":"https:\/\/doi.org\/10.1109\/bibm49941.2020.9313448","mag":"3128444782"},"language":"en","primary_location":{"id":"doi:10.1109\/bibm49941.2020.9313448","is_oa":false,"landing_page_url":"https:\/\/doi.org\/10.1109\/bibm49941.2020.9313448","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https:\/\/openalex.org\/A5039550320","display_name":"Chengxin He","orcid":"https:\/\/orcid.org\/0000-0003-3759-3914"},"institutions":[{"id":"https:\/\/openalex.org\/I4210125143","display_name":"Chengdu University","ror":"https:\/\/ror.org\/034z67559","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I4210125143"]},{"id":"https:\/\/openalex.org\/I24185976","display_name":"Sichuan University","ror":"https:\/\/ror.org\/011ashp19","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chengxin He","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https:\/\/openalex.org\/I4210125143","https:\/\/openalex.org\/I24185976"]}]},{"author_position":"middle","author":{"id":"https:\/\/openalex.org\/A5103153652","display_name":"Lei Duan","orcid":"https:\/\/orcid.org\/0000-0001-7254-1832"},"institutions":[{"id":"https:\/\/openalex.org\/I24185976","display_name":"Sichuan University","ror":"https:\/\/ror.org\/011ashp19","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I24185976"]},{"id":"https:\/\/openalex.org\/I4210125143","display_name":"Chengdu University","ror":"https:\/\/ror.org\/034z67559","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I4210125143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Duan","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https:\/\/openalex.org\/I4210125143","https:\/\/openalex.org\/I24185976"]}]},{"author_position":"middle","author":{"id":"https:\/\/openalex.org\/A5024401909","display_name":"Huiru Zheng","orcid":"https:\/\/orcid.org\/0000-0001-7648-8709"},"institutions":[{"id":"https:\/\/openalex.org\/I138801177","display_name":"University of Ulster","ror":"https:\/\/ror.org\/01yp9g959","country_code":"GB","type":"education","lineage":["https:\/\/openalex.org\/I138801177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Huiru Zheng","raw_affiliation_strings":["School of Computing, Ulster University, Northern Ireland, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Computing, Ulster University, Northern Ireland, United Kingdom","institution_ids":["https:\/\/openalex.org\/I138801177"]}]},{"author_position":"middle","author":{"id":"https:\/\/openalex.org\/A5042718871","display_name":"Jesse Li\u2010Ling","orcid":"https:\/\/orcid.org\/0000-0003-1723-9088"},"institutions":[{"id":"https:\/\/openalex.org\/I24185976","display_name":"Sichuan University","ror":"https:\/\/ror.org\/011ashp19","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jesse Li-Ling","raw_affiliation_strings":["State Laboratory of Biotherapy, Sichuan University, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"State Laboratory of Biotherapy, Sichuan University, Chengdu, China","institution_ids":["https:\/\/openalex.org\/I24185976"]}]},{"author_position":"last","author":{"id":"https:\/\/openalex.org\/A5004606852","display_name":"Longhai Li","orcid":"https:\/\/orcid.org\/0000-0002-3074-8584"},"institutions":[{"id":"https:\/\/openalex.org\/I4210125143","display_name":"Chengdu University","ror":"https:\/\/ror.org\/034z67559","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I4210125143"]},{"id":"https:\/\/openalex.org\/I24185976","display_name":"Sichuan University","ror":"https:\/\/ror.org\/011ashp19","country_code":"CN","type":"education","lineage":["https:\/\/openalex.org\/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longhai Li","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https:\/\/openalex.org\/I4210125143","https:\/\/openalex.org\/I24185976"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https:\/\/openalex.org\/A5039550320"],"corresponding_institution_ids":["https:\/\/openalex.org\/I24185976","https:\/\/openalex.org\/I4210125143"],"apc_list":null,"apc_paid":null,"fwci":0.0829,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4636488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"269","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https:\/\/openalex.org\/T11765","display_name":"Circular RNAs in diseases","score":1,"subfield":{"id":"https:\/\/openalex.org\/subfields\/1312","display_name":"Molecular Biology"},"field":{"id":"https:\/\/openalex.org\/fields\/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https:\/\/openalex.org\/domains\/1","display_name":"Life Sciences"}},"topics":[{"id":"https:\/\/openalex.org\/T11765","display_name":"Circular RNAs in diseases","score":1,"subfield":{"id":"https:\/\/openalex.org\/subfields\/1312","display_name":"Molecular Biology"},"field":{"id":"https:\/\/openalex.org\/fields\/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https:\/\/openalex.org\/domains\/1","display_name":"Life Sciences"}},{"id":"https:\/\/openalex.org\/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https:\/\/openalex.org\/subfields\/1306","display_name":"Cancer Research"},"field":{"id":"https:\/\/openalex.org\/fields\/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https:\/\/openalex.org\/domains\/1","display_name":"Life Sciences"}},{"id":"https:\/\/openalex.org\/T10062","display_name":"MicroRNA in disease regulation","score":0.9988999962806702,"subfield":{"id":"https:\/\/openalex.org\/subfields\/1306","display_name":"Cancer Research"},"field":{"id":"https:\/\/openalex.org\/fields\/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https:\/\/openalex.org\/domains\/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https:\/\/openalex.org\/keywords\/microrna","display_name":"microRNA","score":0.6879262924194336},{"id":"https:\/\/openalex.org\/keywords\/disease","display_name":"Disease","score":0.6055459976196289},{"id":"https:\/\/openalex.org\/keywords\/rna","display_name":"RNA","score":0.5413368344306946},{"id":"https:\/\/openalex.org\/keywords\/messenger-rna","display_name":"Messenger RNA","score":0.5391523838043213},{"id":"https:\/\/openalex.org\/keywords\/computer-science","display_name":"Computer science","score":0.47827255725860596},{"id":"https:\/\/openalex.org\/keywords\/computational-biology","display_name":"Computational biology","score":0.43949079513549805},{"id":"https:\/\/openalex.org\/keywords\/drama","display_name":"Drama","score":0.42339026927948},{"id":"https:\/\/openalex.org\/keywords\/biology","display_name":"Biology","score":0.2873924970626831},{"id":"https:\/\/openalex.org\/keywords\/gene","display_name":"Gene","score":0.2678253650665283},{"id":"https:\/\/openalex.org\/keywords\/genetics","display_name":"Genetics","score":0.2488383650779724},{"id":"https:\/\/openalex.org\/keywords\/medicine","display_name":"Medicine","score":0.23578187823295593},{"id":"https:\/\/openalex.org\/keywords\/pathology","display_name":"Pathology","score":0.1618002951145172},{"id":"https:\/\/openalex.org\/keywords\/art","display_name":"Art","score":0.12306860089302063},{"id":"https:\/\/openalex.org\/keywords\/literature","display_name":"Literature","score":0.09253236651420593}],"concepts":[{"id":"https:\/\/openalex.org\/C145059251","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q310899","display_name":"microRNA","level":3,"score":0.6879262924194336},{"id":"https:\/\/openalex.org\/C2779134260","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q12136","display_name":"Disease","level":2,"score":0.6055459976196289},{"id":"https:\/\/openalex.org\/C67705224","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q11053","display_name":"RNA","level":3,"score":0.5413368344306946},{"id":"https:\/\/openalex.org\/C105580179","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q188928","display_name":"Messenger RNA","level":3,"score":0.5391523838043213},{"id":"https:\/\/openalex.org\/C41008148","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q21198","display_name":"Computer science","level":0,"score":0.47827255725860596},{"id":"https:\/\/openalex.org\/C70721500","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q177005","display_name":"Computational biology","level":1,"score":0.43949079513549805},{"id":"https:\/\/openalex.org\/C523419034","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q25372","display_name":"Drama","level":2,"score":0.42339026927948},{"id":"https:\/\/openalex.org\/C86803240","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q420","display_name":"Biology","level":0,"score":0.2873924970626831},{"id":"https:\/\/openalex.org\/C104317684","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q7187","display_name":"Gene","level":2,"score":0.2678253650665283},{"id":"https:\/\/openalex.org\/C54355233","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q7162","display_name":"Genetics","level":1,"score":0.2488383650779724},{"id":"https:\/\/openalex.org\/C71924100","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q11190","display_name":"Medicine","level":0,"score":0.23578187823295593},{"id":"https:\/\/openalex.org\/C142724271","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q7208","display_name":"Pathology","level":1,"score":0.1618002951145172},{"id":"https:\/\/openalex.org\/C142362112","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q735","display_name":"Art","level":0,"score":0.12306860089302063},{"id":"https:\/\/openalex.org\/C124952713","wikidata":"https:\/\/www.wikidata.org\/wiki\/Q8242","display_name":"Literature","level":1,"score":0.09253236651420593}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109\/bibm49941.2020.9313448","is_oa":false,"landing_page_url":"https:\/\/doi.org\/10.1109\/bibm49941.2020.9313448","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Decent work and economic growth","score":0.7400000095367432,"id":"https:\/\/metadata.un.org\/sdg\/8"}],"awards":[],"funders":[{"id":"https:\/\/openalex.org\/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https:\/\/ror.org\/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https:\/\/openalex.org\/W2002185065","https:\/\/openalex.org\/W2118814218","https:\/\/openalex.org\/W2140310134","https:\/\/openalex.org\/W2154654747","https:\/\/openalex.org\/W2210577735","https:\/\/openalex.org\/W2596298550","https:\/\/openalex.org\/W2734945090","https:\/\/openalex.org\/W2767546566","https:\/\/openalex.org\/W2775753790","https:\/\/openalex.org\/W2782571367","https:\/\/openalex.org\/W2800766678","https:\/\/openalex.org\/W2807602500","https:\/\/openalex.org\/W2884943532","https:\/\/openalex.org\/W2899728356","https:\/\/openalex.org\/W2914026182","https:\/\/openalex.org\/W2944230847","https:\/\/openalex.org\/W2953577247","https:\/\/openalex.org\/W2963757395","https:\/\/openalex.org\/W2964015378","https:\/\/openalex.org\/W2964121744","https:\/\/openalex.org\/W2967043226","https:\/\/openalex.org\/W2972190637","https:\/\/openalex.org\/W2977707586","https:\/\/openalex.org\/W2982780080","https:\/\/openalex.org\/W2983166786","https:\/\/openalex.org\/W3004538479","https:\/\/openalex.org\/W3100848837","https:\/\/openalex.org\/W3146565636"],"related_works":["https:\/\/openalex.org\/W1517284969","https:\/\/openalex.org\/W2354154790","https:\/\/openalex.org\/W2354688617","https:\/\/openalex.org\/W2387588787","https:\/\/openalex.org\/W2902726906","https:\/\/openalex.org\/W131859739","https:\/\/openalex.org\/W3160079251","https:\/\/openalex.org\/W2373684733","https:\/\/openalex.org\/W2386944533","https:\/\/openalex.org\/W2376109006"],"abstract_inverted_index":{"Non-coding":[0],"RNAs":[1],"are":[2],"gaining":[3],"prominence":[4],"in":[5,14],"biology":[6],"and":[7,17,37,44,62,120],"medicine,":[8],"as":[9,68],"they":[10],"play":[11],"major":[12],"roles":[13],"cellular":[15],"homeostasis":[16],"disease.":[18],"A":[19],"large":[20],"number":[21],"of":[22,32,65,76,114,130,154,173],"computational":[23],"methods":[24,52],"have":[25,53],"been":[26],"recently":[27],"developed":[28],"for":[29,92],"the":[30,33,42,57,60,74,77,82,98,111,127,131,147,152,174],"prediction":[31],"relationship":[34],"between":[35,59],"ncRNAs":[36,66,80],"diseases,":[38],"which":[39],"can":[40],"alleviate":[41],"time-consuming":[43],"labor-intensive":[45],"exploration":[46],"among":[47,79],"biological":[48,116],"experiments.":[49],"However,":[50],"such":[51,67],"mainly":[54],"focused":[55],"on":[56,81,126,146,159,171],"association":[58],"disease":[61],"certain":[63],"types":[64],"miRNA":[69],"or":[70],"circRNA,":[71],"thereby":[72],"ignoring":[73],"impact":[75],"interactions":[78],"diseases.":[83],"We":[84],"hereby":[85],"propose":[86],"a":[87,137],"novel":[88],"approach":[89],"called":[90],"DRAMA":[91,166],"discovering":[93],"disease-related":[94,142],"circRNA-miRNA-mRNA":[95,143],"axes":[96,144],"from":[97],"disease-RNA":[99],"information":[100,124],"network":[101],"we":[102,135,156],"constructed.":[103],"Our":[104],"method,":[105],"using":[106],"graph":[107],"convolutional":[108],"network,":[109],"learns":[110],"characteristic":[112],"representation":[113],"each":[115],"entity":[117],"by":[118],"propagating":[119],"aggregating":[121],"local":[122],"neighbor":[123],"based":[125,145],"global":[128],"structure":[129],"network.":[132],"And":[133],"then":[134],"design":[136],"favorable":[138],"measurement":[139],"to":[140],"infer":[141],"learned":[148],"embeddings.":[149],"To":[150],"evaluate":[151],"effectiveness":[153],"DRAMA,":[155],"conduct":[157],"experiments":[158],"real-world":[160],"datasets.":[161],"Further":[162],"analysis":[163],"reveals":[164],"that":[165],"outperforms":[167],"other":[168],"state-of-the-art":[169],"baselines":[170],"most":[172],"metrics.":[175]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}