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A.D.S. is a member of the Scientific Advisory Board of the German Society for Digital Medicine and a member of the Strategic Advisory Board of HumanFirst. She declares consulting income from the U.S. Department of Health and Human Services unrelated to the topic of this article. F.T.B. is a Co-Director of the Harvard-MIT Center for Regulatory Science and receives support from the Center unrelated to the current work. J.T. is a co-founder of Precision Mental Wellness, unrelated to this work. J.T. is an Associate Editor of npj Digital Medicine.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"121"}}