Department of Sciences, Chemistry

Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to inhibit tumors that overexpress VDR. However, the current antagonists are arduous to synthesize and are only partial antagonists, limiting their use. Here, we show that the VDR antagonist MeTC7 (5), which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo. The VDR selectivity of 5 against RXRα and PPAR-γ was confirmed, and docking studies using VDR-LBD indicated that 5 induces major changes in the binding motifs, which potentially result in VDR antagonistic effects. These data highlight the therapeutic benefits of targeting VDR for the treatment of malignancies and demonstrate the creation of selective VDR antagonists that are easy to synthesize.

Carboxy-terminated polyvinylpyrrolidin-2-one (PVP) has been used as a new water-soluble and biocompatible polymeric support for a series of ferrocene labeled amino acid and peptide nucleic acid (PNA) monomer derivatives 4-7. The organometallic polymer-conjugates thus obtained are new and potentially useful as water-soluble electrochemically active probes for biomolecules. In view of such application, their electrochemical activity has been evaluated and has proved very high notwithstanding the complexity and bulkiness of the molecule, affording detection limits down to 10 À8 M in the aqueous medium.

Schiff Base ligands and their application have aroused considerable interest mainly due to preparative accessibility, diverse reactivity and structural variability. Metal complexes of Schiff base have played a vital role in the development of coordination chemistry and many applications in

Synthesis of silver nanoparticles with suitable attributes is important for its successful application. Green methods of synthesis have many advantages as compared to commonly used chemical and physical methods. Biopolymers provide a suitable condition for the synthesis, growth, and stability of nanoparticles. A biopolymer which does not put pressure on resources, biocompatible obtained as waste and easily available has the potential for application in the synthesis of AgNP. Biopolymer which is a waste from paper manufacturing process has been employed to synthesize AgNP, and the synthesis has been confirmed by UV-Vis spectroscopy. The role of the biopolymer in the synthesis of stable AgNP has been confirmed by FTIR and TEM.

The 3D modeling is an important research area in Geographical Information System (GIS) and related fields. Many of the GIS applications need the actual data of the three dimensional (3D) value for their modeling. The 3D visualization of the spatial data gives more ideas about the terrains. The 3DGIS technologies comprise of the combination of GIS and Information Technology (IT).The advancement in the computer and web related technologies boosted the research of 3D GIS. Currently several open source software are available for modeling and developmental purpose. The present study used Cesium JavaScript library for 3D rendering and its customization. Wamp server one of the premier webserver is used for the webhosting. For the development of user interface, HTML and PHP based scripting language was used. The present study aims to design and develop a 3DWeb GIS application for effective visualization, utilization of information and dissemination of spatial data of Karunagappally Municipa...

Human-induced alterations of the landscape and the same driven climate changes are seriously making drastic changes in the processes on the Earth's surface, regionally and globally. Visible Infrared Imaging Radiometer Suite (VIIRS) night-time light datasets can precisely detect the intensity and scope of human activities. Accurate and temporal monitoring of urban areas and urban sprawls is highly imperative to the detection and assessment of regional development of a region. This study quantitatively assessed and mapped the light extents and urban region in Kerala, one of the southwest Indian states from 2012 to 2020 with the help of low light imaging day/ night band data collected from the VIIRS and utilised VIIRS night time Lights V.2 time series from the monthly averages with filtering to eliminate extraneous features such as aurora, biomass burning, and background. ISO-CLUSTER based classification and the threshold methods are used for the light extent and urban region extraction respectively. The result indicated that the Kerala State experienced very high urbanization from 2012 to 2019. But in the case of 2020, there was a decrement in the radiance due to the lockdown and night curfews followed by the COVID-19 global pandemic. Normal life including transportation, industries, and business, etc. was affected much before the national lockdown in Kerala. It was proved with the help of time series data generated from mid-2019 to the end of 2020. The time-series data was generated with 580 night light datasets of NASA's Black Marble VNP46A2 from 1st June 2019 to 31st December 2020 on daily basis.

Now a day's many applications and modeling fields required the data containing the actual three dimensional data. Most of the applications require Cloud GIS for visualization as well as the analysis in terms of spatial relationship. The present study analyses the essential techniques to realize Cloud GIS visualization were studied. The wellknown qgis cloud platform was used for the developmental part of the study. The present study was presented in two parts for the developmental easiness. The first part includes the delineation and preparation of geographical layers of the study area. The second part involves the developmental side using JavaScript.

Web geoservices is the obvious graduation of Geographic Information System in a distributed environment through a simple browser. It enables organizations to share domain-specific rich and dynamic spatial information over the web. The present study attempted to design and develop a web enabled GIS application for the

Now a day's many applications and modeling fields required the data containing the actual three dimensional data. Most of the applications require Cloud GIS for visualization as well as the analysis in terms of spatial relationship. The present study analyses the essential techniques to realize Cloud GIS visualization were studied. The wellknown qgis cloud platform was used for the developmental part of the study. The present study was presented in two parts for the developmental easiness. The first part includes the delineation and preparation of geographical layers of the study area. The second part involves the developmental side using JavaScript.