Xiaobing Yu, MD
Associate Professor
Anesthesia
School of Medicine

He provides innovative interventional procedures guided by ultrasound or fluoroscopy (an imaging technique using continuous X-rays) to treat many chronic and persistent pain conditions. These include orofacial pain (such as trigeminal neuralgia), failed back surgery syndrome, facetogenic pain (involving the facet joints of the spine's vertebrae), neuropathic pain, complex regional pain syndrome and pain associated with cancer.

Dr. Yu’s clinical background provides crucial insight into identifying research niche to improve patient care. Supported by the NIH, foundation grants, and intramural fundings, his research is focused on investigating the contribution of neuroimmune interaction between tissue resident immune cells and nociceptors to neuropathic diseases using both preclinical animal models and patient induced pluripotent stem cell (iPSC)-derived disease model.

As a physician scientist, Dr. Yu is committed to inspiring brilliant, diverse trainees to pursue a career path to lead future academic medicine. He is the clerkship director of both Anes 140.06 and 130.01, and the director of resident chronic pain rotation. In addition to clinical mentoring, Dr. Yu has served as the research mentor of postdoctoral researchers, graduate students, NIH Diversity Supplement Award for predoctoral candidates, the Medical Student Anesthesia Research Fellowship, Pathway to Discovery Learner and Deep Explore Project.

• Contribution of colony-stimulating factor 1 to neuropathic pain.
  Pain reports 2021 Yu X, Basbaum A, Guan Z
• Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva.
  Biomedicines 2021 Khan F, Yu X, Hsiao EC
• Maxillary Nerve-Mediated Postseptoplasty Nasal Allodynia: A Case Report.
  A&A practice 2020 Sharma S, Ly W, Yu X
• Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain.
  Nature communications 2020 Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI
• Rapid Isolation of Dorsal Root Ganglion Macrophages.
  Journal of visualized experiments : JoVE 2019 Yu X, Leff J, Guan Z
• Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report.
  A&A practice 2018 Peniche A, Poree L, Schumacher M, Yu X
• T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.
  The Journal of biological chemistry 2012 Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT
• Erythropoietin signaling promotes transplanted progenitor cell survival.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Jia Y, Warin R, Yu X, Epstein R, Noguchi CT
• Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models.
  Cell research 2009 Pomper MG, Hammond H, Yu X, Ye Z, Foss CA, Lin DD, Fox JJ, Cheng L
• Id1 delays senescence of primary human melanocytes.
  Molecular carcinogenesis 2008 Cummings SD, Ryu B, Samuels MA, Yu X, Meeker AK, Healey MA, Alani RM
• Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts.
  Stem cells (Dayton, Ohio) 2008 Mali P, Ye Z, Hommond HH, Yu X, Lin J, Chen G, Zou J, Cheng L
• Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment.
  Cell stem cell 2008 Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L
• Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Alder JK, Georgantas RW, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M, Civin CI
• Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins.
  Cell stem cell 2008 Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L
• Lentiviral gene transduction of mouse and human stem cells.
  Methods in molecular biology (Clifton, N.J.) 2008 Ye Z, Yu X, Cheng L
• Hypoxia alters progression of the erythroid program.
  Experimental hematology 2007 Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT
• Modification of globin gene expression by RNA targeting strategies.
  Experimental hematology 2007 Shen TJ, Rogers H, Yu X, Lin F, Noguchi CT, Ho C
• FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells.
  British journal of haematology 2007 Li L, Piloto O, Kim KT, Ye Z, Nguyen HB, Yu X, Levis M, Cheng L, Small D
• A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
  Nature genetics 2007 Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB
• HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding.
  Stem cells (Dayton, Ohio) 2006 Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI
• Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells.
  Stem cells (Dayton, Ohio) 2005 Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L
• Tal1/SCL binding to pericentromeric DNA represses transcription.
  The Journal of biological chemistry 2005 Wen J, Huang S, Pack SD, Yu X, Brandt SJ, Noguchi CT
• Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.
  Development (Cambridge, England) 2004 Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD
• Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells.
  Blood 2004 Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT
• High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system.
  The Journal of investigative dermatology 2004 Dunlap S, Yu X, Cheng L, Civin CI, Alani RM
• Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells.
  Molecular therapy : the journal of the American Society of Gene Therapy 2003 Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L
• Erythropoietin receptor signalling is required for normal brain development.
  Development (Cambridge, England) 2002 Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT
• Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele.
  Blood cells, molecules & diseases 2001 Noguchi CT, Gladwin M, Diwan B, Merciris P, Smith R, Yu X, Buzard G, Fitzhugh A, Keefer LK, Schechter AN, Mohandas N
• The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse.
  Blood 2001 Yu X, Lin CS, Costantini F, Noguchi CT
• Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts.
  The Journal of biological chemistry 2000 Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, Ruegg UT, Noguchi CT
• Production and processing of erythropoietin receptor transcripts in brain.
  Brain research. Molecular brain research 2000 Chin K, Yu X, Beleslin-Cokic B, Liu C, Shen K, Mohrenweiser HW, Noguchi CT