Max Cohen, MD, PhD
Provider
EVP-Clinical Integrated N.Work
Chancellor/EVC/FAS

I'm a pulmonary & critical care physician, specializing in diseases of the lung alveolus, such as Interstitial Lung Diseases (especially Idiopathic Pulmonary Fibrosis) and Acute Respiratory Distress Syndrome (ARDS).

Interests

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• Acute Respiratory Distress Syndrome
• Idiopathic Pulmonary Fibrosis
• Epithelial-Mesenchymal Interactions
• Stem Cells
• Interstitial Lung Disease
• Lung Biology

Grants and Projects

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• Functions of Branched-Chain Fatty Acids in the Nematode Worm C. elegans, NIH, 2010-2012
• Reprogramming of type 2 alveolar epithelial cells in idiopathic pulmonary fibrosis and regulation by TGFb1., NIH, 2021-1900

Publications (9)

Top publication keywords:
Transforming Growth Factor beta1Caenorhabditis elegans ProteinsWnt Signaling PathwayKeratin-5Cell TransdifferentiationIdiopathic Pulmonary FibrosisCollagen Type IFibroblastsAmino Acid OxidoreductasesTranscription, GeneticAlveolar Epithelial CellsMicroRNAsAngiopoietin-2MetaplasiaGATA Transcription Factors

• A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.
  The Journal of clinical investigation 2024 Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ
• A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis.
  bioRxiv : the preprint server for biology 2023 Cohen ML, Brumwell AN, Che Ho T, Montas G, Golden JA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ
• Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
  Nature cell biology 2021 Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T
• Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.
  Thorax 2021 Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA
• Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.
  BMC nephrology 2020 Bhatraju PK, Cohen M, Nagao RJ, Morrell ED, Kosamo S, Chai XY, Nance R, Dmyterko V, Delaney J, Christie JD, Liu KD, Mikacenic C, Gharib SA, Liles WC, Zheng Y, Christiani DC, Himmelfarb J, Wurfel MM

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• Interaction Between Epithelial and Mesenchymal Cells in Interstitial Lung Disease
  Encyclopedia of Respiratory Medicine, Second Edition 2020 Max L Cohen, Paul J Wolters
• Lung Herniation: An Unusual Cause of Chest Pain
  Southwest Journal of Pulmonary and Critical Care 2015 Cohen ML, Rayamajhi S, Kurche JS, Welsh CH
• The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.
  PLoS genetics 2015 Cohen ML, Kim S, Morita K, Kim SH, Han M
• The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans.
  Current biology : CB 2013 Cui M, Cohen ML, Teng C, Han M