Mark Lu, MD, PhD
Professor
Laboratory Medicine
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2020

Publications (41)

Top publication keywords:
Bone MarrowVitamin DBlast CrisisUbiquitin-Activating EnzymesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveHypereosinophilic SyndromeMyelodysplastic SyndromesThrombocytosisMyeloproliferative DisordersPartial Thromboplastin TimeAnemia, RefractoryFactor VIIIAnemia, SideroblasticHIV SeropositivityPathology, Clinical

• DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis.
  Science translational medicine 2025 Sun S, Yin Z, Van Cleave JG, Wang L, Fried B, Bilal KH, Lucas F, S Isgor I, Webb DC, Singi S, Brown L, Shouval R, Lin J, Yan ES, Spector JD, Ardon O, Boiocchi L, Sardana R, Baik J, Zhu M, Syed A, Yabe…
• Rapid detection of SARS-CoV-2 variants by molecular-clamping technology-based RT-qPCR.
  Microbiology spectrum 2024 Shen S, Fu AY, Jamba M, Li J, Cui Z, Pastor L, Cataldi D, Sun Q, Pathakamuri JA, Kuebler D, Rohall M, Krohn M, Kissinger D, Neves J, Archibeque I, Zhang A, Lu CM, Sha MY
• How I diagnose and manage VEXAS syndrome.
  American journal of clinical pathology 2024 Hagiya A, Siddiqi IN, Wang E, Lu CM
• A novel XNA-based Luminex assay to detect UBA1 somatic mutations associated with VEXAS syndrome.
  Practical laboratory medicine 2024 Ma Y, Hu S, Ni R, Liu W, Fu A, Sha M, Zhang A, Lu CM
• DeepHeme: A generalizable, bone marrow classifier with hematopathologist-level performance.
  bioRxiv : the preprint server for biology 2023 Goldgof GM, Sun S, Van Cleave J, Wang L, Lucas F, Brown L, Spector JD, Boiocchi L, Baik J, Zhu M, Ardon O, Lu CM, Dogan A, Goldgof DB, Carmichael I, Prakash S, Butte AJ

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• Clinical Response to Upfront Targeted Tyrosine Kinase Inhibitors among Patients with Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusion.
  Clinical lymphoma, myeloma & leukemia 2022 Zhang Y, Nguyen L, Lu CM, Wang E, Lauw MIS, Ball S, Dong N, Moscinski L, Chan O, Yun S, Sallman D, Sokol L, Shah B, Knepper T, Lancet J, Komrokji R, Padron E, Kuykendall A, Zhang L
• A new testing platform using fingerstick blood for quantitative antibody response evaluation after SARS-CoV-2 vaccination.
  Emerging microbes & infections 2022 Du J, Zhang D, Pathakamuri JA, Kuebler D, Yang Y, Loginova Y, Chu E, Madej R, Neves JV, Singer B, Radke H, Spencer N, Rizk E, Zhang A, Lu CM, Sha MY
• Novel assays to investigate the mechanisms of latent infection with HIV-2.
  PloS one 2022 Lu MD, Telwatte S, Kumar N, Ferreira F, Martin HA, Kadiyala GN, Wedrychowski A, Moron-Lopez S, Chen TH, Goecker EA, Coombs RW, Lu CM, Wong JK, Tsibris A, Yukl SA
• Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.
  Journal of general internal medicine 2022 Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM
• Diagnosis of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma on pleural fluid cytology.
  Diagnostic cytopathology 2021 Greenland NY, Lu CM, Cook S, Peng Y
• Association between household exposure and cycle threshold in COVID-19 infected health care workers.
  Journal of occupational medicine and toxicology (London, England) 2021 Chien A, Domeracki S, Guntur S, Taylor K, Lu CM, Lampiris H, Blanc PD
• Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA.
  Journal of virological methods 2021 Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
• Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test.
  PloS one 2021 Sun Q, Li J, Ren H, Pastor L, Loginova Y, Madej R, Taylor K, Wong JK, Zhang Z, Zhang A, Lu CM, Sha MY
• Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without.
  Journal of clinical pathology 2021 Luedke C, Zhao Y, McCracken J, Maule J, Yang LH, Jug R, Galeotti J, Siddiqi I, Gong J, Lu CM, Wang E
• Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2.
  bioRxiv : the preprint server for biology 2021 Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
• Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
  Journal of virology 2020 Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S
• A high-throughput Anti-SARS-CoV-2 IgG testing platform for COVID-19.
  Journal of virological methods 2020 Du J, Chu E, Zhang D, Lu CM, Zhang A, Sha MY
• Cycle Threshold to Test Positivity in COVID-19 for Return to Work Clearance in Health Care Workers.
  Journal of occupational and environmental medicine 2020 Domeracki S, Clapp RN, Taylor K, Lu CM, Lampiris H, Blanc PD
• SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood.
  Nature communications 2020 Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, …
• Contemporary Classification and Diagnostic Evaluation of Hypereosinophilia.
  American journal of clinical pathology 2020 Mattis DM, Wang SA, Lu CM
• SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.
  medRxiv : the preprint server for health sciences 2020 Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, …
• Chronic Myeloid Leukemia Following Treatment for Primary Neoplasms or Other Medical Conditions.
  American journal of clinical pathology 2018 Yang LH, Su P, Luedke C, Lu CM, Louissaint A, McCall CM, Rapisardo S, Vallangeon B, Wang E
• Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.
  American journal of clinical pathology 2017 Wu B, Ingersoll K, Jug R, Yang LH, Luedke C, Lo A, Su P, Liu X, Rehder C, Gong J, Lu CM, Wang E
• The Challenges of Precision Medicine and New Advances in Molecular Diagnostic Testing in Hematolymphoid Malignancies: Impact on the VHA.
  Federal practitioner : for the health care professionals of the VA, DoD, and PHS 2017 Wang-Rodriguez J, Yunes A, Phan R, Ma N, Baddoura F, Mosse C, Kim AS, Lu CM, Dong DZM, Schichman S, Icardi M, Ehsan A
• Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA
• Pathology consultation on anticoagulation monitoring: factor X-related assays.
  American journal of clinical pathology 2013 Wool GD, Lu CM, Education Committee of the Academy of Clinical Laboratory Physicians and Scientists
• Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature.
  Archives of pathology & laboratory medicine 2013 Alley CL, Wang E, Dunphy CH, Gong JZ, Lu CM, Boswell EL, Burchette J, Lagoo AS
• Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens.
  American journal of clinical pathology 2012 Reddi DM, Lu CM, Fedoriw G, Liu YC, Wang FF, Ely S, Boswell EL, Louissaint A, Arcasoy MO, Goodman BK, Wang E
• Commentary.
  Clinical chemistry 2012 Lu CM
• Pathology consultation on vitamin D testing: clinical indications for 25(OH) vitamin D measurement.
  American journal of clinical pathology 2012 Lu CM
• Development of refractory anemia with ring sideroblasts associated with thrombocytosis from pre-existing refractory anemia with ring sideroblasts through acquisition of Jak2 V617F mutation.
  Leukemia & lymphoma 2011 Lu CM, Zhou L, Wang E, Feng S, Sebastian S, Behler C
• Presence of complex t(6;9;22;15) four-way chromosome rearrangement plus rare t(1;6) translocation with favorable response to imatinib therapy in chronic myelogenous leukemia.
  Leukemia & lymphoma 2011 Lu CM, Zhou L, Feng S, Kohn PH, Qi Z, Yu J
• Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter.
  Journal of virological methods 2011 Yukl SA, Li P, Fujimoto K, Lampiris H, Lu CM, Hare CB, Deeks SG, Liegler T, Pandori M, Havlir DV, Wong JK
• Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature.
  American journal of clinical pathology 2011 Wang E, Hutchinson CB, Huang Q, Lu CM, Crow J, Wang FF, Sebastian S, Rehder C, Lagoo A, Horwitz M, Rizzieri D, Yu J, Goodman B, Datto M, Buckley P
• Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly.
  American journal of clinical pathology 2011 Wang E, Boswell E, Siddiqi I, Lu CM, Sebastian S, Rehder C, Huang Q
• Check Sample Abstracts.
  American journal of clinical pathology 2009 Alter D, Grenache DG, Bosler DS, Karcher RE, Nichols J, Rajadhyaksha A, Camelo-Piragua S, Rauch C, Huddleston BJ, Frank EL, Sluss PM, Lewandrowski K, Eichhorn JH, Hall JE, Rahman SS, McPherson RA, …
• Measurement of microalbuminuria using protein chip electrophoresis.
  American journal of clinical pathology 2008 Pandey S, Lu CM, Herold DA
• Simultaneous presence of major secondary chromosomal abnormalities in blast crisis of chronic myeloid leukemia.
  Cancer genetics and cytogenetics 2007 Lu CM, Wang E, Lawrence HJ
• Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases.
  American journal of hematology 2006 Lu CM, Murata-Collins JL, Wang E, Siddiqi I, Lawrence H
• Erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia and subsequent transformation to acute myeloid leukemia.
  American journal of hematology 2005 Etzell J, Lu CM, Browne LW, Wang E
• Mass spectrometric immunoassay for parathyroid hormone-related protein.
  Analytical chemistry 2002 Lu CM, Burton WD, Fitzgerald RL, Deftos LJ, Buchholz BA, Vogel JS, Herold DA