Li Wang, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Education & Training

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• Mechanosensitive Piezo ion Channels Tsinghua University 01/2021

Publications (7)

Top publication keywords:
Ion TransportGenetic SpeciationDNA, PlantAutocrine CommunicationIon Channelsbeta CateninCryoelectron MicroscopyTransforming Growth Factor beta1Protein DomainsParacrine CommunicationIon Channel GatingActin CytoskeletonCytoskeletonIntegrinsMechanotransduction, Cellular

• An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel.
  Neuron 2024 Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
• Dynamic allostery drives autocrine and paracrine TGF-β signaling.
  Cell 2024 Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
• Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex.
  Cell reports 2022 Wang J, Jiang J, Yang X, Zhou G, Wang L, Xiao B
• A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.
  Neuron 2020 Geng J, Liu W, Zhou H, Zhang T, Wang L, Zhang M, Li Y, Shen B, Li X, Xiao B
• Structure and mechanogating of the mammalian tactile channel PIEZO2.
  Nature 2019 Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, Li Y, Lei J, Li X, Xiao B
• A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel.
  Nature communications 2018 Wang Y, Chi S, Guo H, Li G, Wang L, Zhao Q, Rao Y, Zu L, He W, Xiao B
• Extensive and heritable epigenetic remodeling and genetic stability accompany allohexaploidization of wheat.
  Genetics 2011 Zhao N, Zhu B, Li M, Wang L, Xu L, Zhang H, Zheng S, Qi B, Han F, Liu B