Brian Orr, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Publications (8)

Top publication keywords:
Epithelial Sodium ChannelsNerve Tissue ProteinsTalinPresynaptic TerminalsNerve Growth FactorsNeuromuscular JunctionHomeostasisNeuronal PlasticityDrosophila melanogasterDrosophila ProteinsReceptors, Cell SurfaceSemaphorinsNeuroprotectionTumor Suppressor ProteinsAminobutyrates

• A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses.
  Neuron 2025 Chipman PH, Lee U, Orr BO, Fetter RD, Davis GW
• Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders.
  bioRxiv : the preprint server for biology 2025 Ellegood J, Beauchamp A, Yee Y, Devenyi G, Ziolkowski J, Qiu L, Askalan R, Ayub M, Suetterlin P, Donovan A, Basson MA, Quesnel KM, Berube NG, Woo T, Beversdorf D, Bjornsson H, Blakely R, Crawley J, …
• Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity.
  Neuron 2022 Orr BO, Fetter RD, Davis GW
• SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
  Nature communications 2021 Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW
• Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection.
  Neuron 2020 Orr BO, Hauswirth AG, Celona B, Fetter RD, Zunino G, Kvon EZ, Zhu Y, Pennacchio LA, Black BL, Davis GW
• Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity.
  Nature 2017 Orr BO, Fetter RD, Davis GW
• Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.
  Cell reports 2017 Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW
• Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Orr BO, Borgen MA, Caruccio PM, Murphey RK