Bu çalışmada klorojenik asidin (KA) farklı konsantrasyonlarının (100 µg/mL, 150 µg/mL, 300 µg/mL ... more Bu çalışmada klorojenik asidin (KA) farklı konsantrasyonlarının (100 µg/mL, 150 µg/mL, 300 µg/mL ve 500 µg/mL) tek başına ve Tekamen (40 µg/mL) ile birlikte farklı sürelerde (24, 48 ve 72 saat) insan servikal kanser (HeLa) hücre hattı ve insan periferal lenfositleri üzerindeki in vitro sitotoksik etkisi MTT ve WST-8 canlılık testleri ile belirlenmiştir. Çalışmada negatif kontrol olarak sadece besiyeri içeren HeLa hücreleri, çözücü kontrol olarak KA'nın çözücüsü %0.1'lik DMSO ve pozitif kontrol olarak da Tekamen kullanılmıştır. KA muamelesinin HeLa hücreleri üzerinde önemli bir sitotoksik etki göstermediği ortaya çıkmıştır. KA+Tekamen karışımının, HeLa hücreleri üzerinde gösterdiği sitotoksik etkinin KA'nın gösterdiği sitotoksik etkiden daha fazla olduğu görülmüştür. KA+Tekamen karışımının sitotoksik etkisi kontrol grupları ile karşılaştırıldığında aradaki fark istatistiki açıdan anlamlı bulunmuştur (p<0.05). KA ile muamele edilen periferal lenfositlerde, KA'nın ön...
As in the past, today, antimicrobial products remain important in public health. Antimicrobial pr... more As in the past, today, antimicrobial products remain important in public health. Antimicrobial products used to protect against epidemic during the pandemic attracted the attention of the public. Antimicrobial agents stops or decelerates the spread of microorganisms. Microorganisms include bacteria, viruses, protozoans, and fungi. Increasing the effectiveness of antimicrobial products against microorganisms is very important today. Antimicrobial products we can see in every area of our daily life in house, workplace, or at school. In this review, we aimed to give brief information under the headings impact mechanisms of antimicrobials, production sources of antimicrobials new generation antimicrobials; what is safe antimicrobial in public health?
Central nervous system (CNS) diseases have a very important place in terms of public health. Epil... more Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
A New Approach in Epilepsy Treatment Nano-Carrier Systems, 2021
Central nervous system (CNS) diseases have a very important place in terms of public health. Epil... more Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
Central nervous system (CNS) diseases have a very important place in terms of public health. Epil... more Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
The Relationship Mechanism Between Covid-19 and Renin-Angiotensin System, 2020
Coronaviruses (CoVs) are a group of ribonucleic acid (RNA) viruses that can cause respiratory, in... more Coronaviruses (CoVs) are a group of ribonucleic acid (RNA) viruses that can cause respiratory, intestinal and central nervous system infections in humans and animals. Especially two strains caused severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In addition to these strains, SARS-coronavirus 2 (SARS-CoV-2), appeared in Wuhan, China in December 2019. It soon affected the whole world and was declared a pandemic by the World Health Organization. The disease caused by the SARS-CoV-2 virus is called coronavirus disease (Covid-19). There are studies in the literature, infection mechanism of Covid-19, is binding of the virus to the receptor of angiotensin converting enzyme-2 (ACE2) and subsequently internalization of the complex by the host cell. The recognition of ACE2 as a co-receptor for SARS-CoV-2 suggest that there is cellular entry in ACE2 expressing tissues, including lung, heart, kidney, brain and intestine. The studies, have extensively studied the RBD-ACE2 complex, spike protein, and free RBD systems of SARS-CoV-2 and SARS-CoV using protein-protein docking and molecular dynamics simulations. The free binding energy of SARS-CoV-2 to RBD-ACE2 has been shown to be lower than the free binding energies of other coronavirus types. It was emphasized that this situation could be related to the more contagious SARS-CoV-2. While it seems such as clear that SARS-CoV-2 infects with binding mechanism the human ACE2 receptor of the RBD domain, the molecular mechanisms still remain mysterious. The present findings are expected to be useful for the disease prevention and control as well as drug and vaccine development of Covid-19.
The Importance of Antimicrobials in the Public Health, 2020
As in the past, today, antimicrobial products remain important in public health. Antimicrobial pr... more As in the past, today, antimicrobial products remain important in public health. Antimicrobial products used to protect against epidemic during the pandemic attracted the attention of the public. Antimicrobial agents stops or decelerates the spread of microorganisms. Microorganisms include bacteria, viruses, protozoans, and fungi. Increasing the effectiveness of antimicrobial products against microorganisms is very important today. Antimicrobial products we can see in every area of our daily life in house, workplace, or at school. In this review, we aimed to give brief information under the headings impact mechanisms of antimicrobials, production sources of antimicrobials new generation antimicrobials; what is safe antimicrobial in public health?
Bu çalışmada klorojenik asidin (KA) farklı konsantrasyonlarının (100 µg/mL, 150 µg/mL, 300 µg/mL ... more Bu çalışmada klorojenik asidin (KA) farklı konsantrasyonlarının (100 µg/mL, 150 µg/mL, 300 µg/mL ve 500 µg/mL) tek başına ve Tekamen (40 µg/mL) ile birlikte farklı sürelerde (24, 48 ve 72 saat) insan servikal kanser (HeLa) hücre hattı ve insan periferal lenfositleri üzerindeki in vitro sitotoksik etkisi MTT ve WST-8 canlılık testleri ile belirlenmiştir. Çalışmada negatif kontrol olarak sadece besiyeri içeren HeLa hücreleri, çözücü kontrol olarak KA'nın çözücüsü %0.1'lik DMSO ve pozitif kontrol olarak da Tekamen kullanılmıştır. KA muamelesinin HeLa hücreleri üzerinde önemli bir sitotoksik etki göstermediği ortaya çıkmıştır. KA+Tekamen karışımının, HeLa hücreleri üzerinde gösterdiği sitotoksik etkinin KA'nın gösterdiği sitotoksik etkiden daha fazla olduğu görülmüştür. KA+Tekamen karışımının sitotoksik etkisi kontrol grupları ile karşılaştırıldığında aradaki fark istatistiki açıdan anlamlı bulunmuştur (p<0.05). KA ile muamele edilen periferal lenfositlerde, KA'nın ön...
As in the past, today, antimicrobial products remain important in public health. Antimicrobial pr... more As in the past, today, antimicrobial products remain important in public health. Antimicrobial products used to protect against epidemic during the pandemic attracted the attention of the public. Antimicrobial agents stops or decelerates the spread of microorganisms. Microorganisms include bacteria, viruses, protozoans, and fungi. Increasing the effectiveness of antimicrobial products against microorganisms is very important today. Antimicrobial products we can see in every area of our daily life in house, workplace, or at school. In this review, we aimed to give brief information under the headings impact mechanisms of antimicrobials, production sources of antimicrobials new generation antimicrobials; what is safe antimicrobial in public health?
Central nervous system (CNS) diseases have a very important place in terms of public health. Epil... more Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
A New Approach in Epilepsy Treatment Nano-Carrier Systems, 2021
Central nervous system (CNS) diseases have a very important place in terms of public health. Epil... more Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
Central nervous system (CNS) diseases have a very important place in terms of public health. Epil... more Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
The Relationship Mechanism Between Covid-19 and Renin-Angiotensin System, 2020
Coronaviruses (CoVs) are a group of ribonucleic acid (RNA) viruses that can cause respiratory, in... more Coronaviruses (CoVs) are a group of ribonucleic acid (RNA) viruses that can cause respiratory, intestinal and central nervous system infections in humans and animals. Especially two strains caused severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In addition to these strains, SARS-coronavirus 2 (SARS-CoV-2), appeared in Wuhan, China in December 2019. It soon affected the whole world and was declared a pandemic by the World Health Organization. The disease caused by the SARS-CoV-2 virus is called coronavirus disease (Covid-19). There are studies in the literature, infection mechanism of Covid-19, is binding of the virus to the receptor of angiotensin converting enzyme-2 (ACE2) and subsequently internalization of the complex by the host cell. The recognition of ACE2 as a co-receptor for SARS-CoV-2 suggest that there is cellular entry in ACE2 expressing tissues, including lung, heart, kidney, brain and intestine. The studies, have extensively studied the RBD-ACE2 complex, spike protein, and free RBD systems of SARS-CoV-2 and SARS-CoV using protein-protein docking and molecular dynamics simulations. The free binding energy of SARS-CoV-2 to RBD-ACE2 has been shown to be lower than the free binding energies of other coronavirus types. It was emphasized that this situation could be related to the more contagious SARS-CoV-2. While it seems such as clear that SARS-CoV-2 infects with binding mechanism the human ACE2 receptor of the RBD domain, the molecular mechanisms still remain mysterious. The present findings are expected to be useful for the disease prevention and control as well as drug and vaccine development of Covid-19.
The Importance of Antimicrobials in the Public Health, 2020
As in the past, today, antimicrobial products remain important in public health. Antimicrobial pr... more As in the past, today, antimicrobial products remain important in public health. Antimicrobial products used to protect against epidemic during the pandemic attracted the attention of the public. Antimicrobial agents stops or decelerates the spread of microorganisms. Microorganisms include bacteria, viruses, protozoans, and fungi. Increasing the effectiveness of antimicrobial products against microorganisms is very important today. Antimicrobial products we can see in every area of our daily life in house, workplace, or at school. In this review, we aimed to give brief information under the headings impact mechanisms of antimicrobials, production sources of antimicrobials new generation antimicrobials; what is safe antimicrobial in public health?
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Papers by Burçak Yavuz
can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.
can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.