Spherical agglomeration using emulsion solvent diffusion method was employed to enhance the disso... more Spherical agglomeration using emulsion solvent diffusion method was employed to enhance the dissolution and physichomechanical properties of Indomethacin. Agglomerated crystals of Indomethacin were prepared by the means of three different solvents; methanol, dichloromethane and distilled water that act as a good, bridging and poor solvents respectively. Indomethacin crystals were also agglomerated in presence of different hydrophilic polymers: polyvinyl pyrrolidone K30 (PVP), polyvinyl alcohol (PVA), polyethylene glycol 400 (PEG400), polyethylene glycol 6000 (PEG 6000) and hydroxyl propyl methylcellulose E5 (HPMC-E5) to investigate the impact of these polymers on the properties of the drug crystals. The agglomerated crystals were characterized by fourier transforms infrared spectroscopy (FTIR), Powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The results of these studies showed a decrease in crystallinity and alteration...
The present study was designed to investigate the effects of different variables on the release p... more The present study was designed to investigate the effects of different variables on the release profile of mefenamic acid from calcium alginate beads formulated using modified emulsification method. Five formulations of beads (F1-F5) with different drug: polymer ratios were prepared in which the amount of drug (1g) was kept constant and the amount of calcium alginate was increased from 1 up to 5g. All the formulated beads were evaluated for percentage yield, entrapped efficiency and in vitro release profile at pH 1.2 and 7.2 dissolution media. For further minimize the release of drug from calcium alginate beads, the selected formulation F3 beads were coated separately with 3% and 6% Eudragit S100 solution using dipping method. The coated beads (F6 and F7) minimized the release of drug both in pH 1.2 and 7.2. The study confirms significant effects of two variables, drug:polymer ratio and coating on the release of drug from beads which can be effectively utilized to control the releas...
The aim of this study was to evaluate rheological properties of pectin solutions to determine the... more The aim of this study was to evaluate rheological properties of pectin solutions to determine the influence of polymer concentration, pH, preservatives and heating duration on viscosity, using Brookfield R/S Plus Rheometer. The results shows that dilute pectin solutions are showing Newtonian, but at a moderate concentration they exhibit the non-Newtonian behavior, and the psudoplastic nature was found to increase with concentration. As the pH of the polymer solution lowered there was increase in viscosity of the system observed, this may be due do the carboxyl acid groups on the pectin chains are neutralize i.e. reduction in ionization, and leads to reduction in hydration of the carboxylic acid groups. As a result of reduced ionisation, the polysaccharide molecules do not repel each other over their entire length. The result shows that pectin solutions are stable at broad range of pH. It was observed that as the temperature or pH of the system increases there was decrease in viscosity.
Spherical agglomeration using emulsion solvent diffusion method was employed to enhance the disso... more Spherical agglomeration using emulsion solvent diffusion method was employed to enhance the dissolution and physichomechanical properties of Indomethacin. Agglomerated crystals of Indomethacin were prepared by the means of three different solvents; methanol, dichloromethane and distilled water that act as a good, bridging and poor solvents respectively. Indomethacin crystals were also agglomerated in presence of different hydrophilic polymers: polyvinyl pyrrolidone K30 (PVP), polyvinyl alcohol (PVA), polyethylene glycol 400 (PEG400), polyethylene glycol 6000 (PEG 6000) and hydroxyl propyl methylcellulose E5 (HPMC-E5) to investigate the impact of these polymers on the properties of the drug crystals. The agglomerated crystals were characterized by fourier transforms infrared spectroscopy (FTIR), Powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The results of these studies showed a decrease in crystallinity and alteration...
The present study was designed to investigate the effects of different variables on the release p... more The present study was designed to investigate the effects of different variables on the release profile of mefenamic acid from calcium alginate beads formulated using modified emulsification method. Five formulations of beads (F1-F5) with different drug: polymer ratios were prepared in which the amount of drug (1g) was kept constant and the amount of calcium alginate was increased from 1 up to 5g. All the formulated beads were evaluated for percentage yield, entrapped efficiency and in vitro release profile at pH 1.2 and 7.2 dissolution media. For further minimize the release of drug from calcium alginate beads, the selected formulation F3 beads were coated separately with 3% and 6% Eudragit S100 solution using dipping method. The coated beads (F6 and F7) minimized the release of drug both in pH 1.2 and 7.2. The study confirms significant effects of two variables, drug:polymer ratio and coating on the release of drug from beads which can be effectively utilized to control the releas...
The aim of this study was to evaluate rheological properties of pectin solutions to determine the... more The aim of this study was to evaluate rheological properties of pectin solutions to determine the influence of polymer concentration, pH, preservatives and heating duration on viscosity, using Brookfield R/S Plus Rheometer. The results shows that dilute pectin solutions are showing Newtonian, but at a moderate concentration they exhibit the non-Newtonian behavior, and the psudoplastic nature was found to increase with concentration. As the pH of the polymer solution lowered there was increase in viscosity of the system observed, this may be due do the carboxyl acid groups on the pectin chains are neutralize i.e. reduction in ionization, and leads to reduction in hydration of the carboxylic acid groups. As a result of reduced ionisation, the polysaccharide molecules do not repel each other over their entire length. The result shows that pectin solutions are stable at broad range of pH. It was observed that as the temperature or pH of the system increases there was decrease in viscosity.
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