Papers by Seyed Jalal Hosseinimehr
Journal of Biomedical Physics & Engineering, 2016
INTRODUCTION: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely ... more INTRODUCTION: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely used by human daily. The radio-protective effects of Hesperidin have been confirmed in various measurement systems. This study aimed to evaluate the effects of Hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the peripheral blood lymphocytes of male rats after gamma radiation. MATERIALS AND METHODS: 64 male rats were divided into eight groups: Control, HES (100 mg/kg b.w, orally, 7 days), whole body irradiation with 2 and 8Gy, pre-administrated with 50 and 100 mg/kg body weight of Hesperidin for 7 days before irradiation with 2 and 8 Gy. 24 hours after radiation, apoptotic lymphocytes were evaluated using PE Annexin V Apoptosis detection I kit and the levels of mRNA for bax and bcl-2 were evaluated by real time reverse transcription polymerase chain reaction. RESULTS: A significant reduction in apoptosis of the lymphocytes was demonstrated in group animals receiving 8 Gy compared to the group which received 2 Gy irradiation (p<0.0001). However, apoptosis significantly increased in group of rats who received Hesp before irradiation (p<0.05). The increase of apoptosis by Hesperidin administration can be attributed to the decreased expression of bax and significantly reduced expression of bcl-2 and finally increasing the ration of bax/bcl-2. CONCLUSION: The results suggest that administration of 50 and 100 mg/kg of Hesperidin induces apoptotic effects by changing expression level of bax, bcl-2 and also the ratio of bax/bcl2.
Mini-Reviews in Medicinal Chemistry, 2014
Ionizing radiation is the more effective therapy to reduce tumor growth through damaging the DNA ... more Ionizing radiation is the more effective therapy to reduce tumor growth through damaging the DNA of cells. In response to DNA damage, cells activate the checkpoint kinases such as CHK2, which signal to initiate repair processes and cell-cycle arrest, until the damaged DNA is repaired. At present, the development of CHK2 inhibitors has provided an interesting strategy for the treatment of cancer by introducing new radiation modifier agents. CHK2 inhibitors can contribute for the improvement of cancer therapy through sensitizing cancerous cells and radioprotection of normal cells against ionizing radiation. This review describes and discusses the most recent inhibitors of CHK2 and presents an evaluation of chemical structures and biological activities. As well as their role in cell growth during exposure to ionizing radiation.
Pharmaceutical and Biomedical Research, Jan 15, 2015
Journal of the Brazilian Chemical Society, 2016
Http Dx Doi Org 10 1080 01635581 2014 865136, Jan 10, 2014
Angiogenesis is the formation of new capillaries from existing vessels. Vascular endothelial grow... more Angiogenesis is the formation of new capillaries from existing vessels. Vascular endothelial growth factor (VEGF) promotes this growth by stimulating endothelial cells, which form vessel walls and transport nutrients and oxygen to tissues. VEGF has been implicated in several diseases, such as cancer and gynecologic disorders. Antiangiogenic agents prevent VEGF from binding to its receptors on the endothelial cell surface, which inhibits vessel development. Antiangiogenic agents have been found to be effective in treating several gynecologic diseases, such as endometriosis and uterine fibroids. Natural products with respect to finding new compounds with antiangiogenic effects are interested. In this review, we have focused on the importance of natural products with antiangiogenic activity in treating some malignant and benign angiogenesis-related gynecological disorders, including endometriosis and uterine fibroids.
Radiation oncology journal, 2015
Trace elements play crucial role in the maintenance of genome stability in the cells. Many endoge... more Trace elements play crucial role in the maintenance of genome stability in the cells. Many endogenous defense enzymes are containing trace elements such as superoxide dismutase and metalloproteins. These enzymes are contributing in the detoxification of reactive oxidative species (ROS) induced by ionizing radiation in the cells. Zinc, copper, manganese, and selenium are main trace elements that have protective roles against radiation-induced DNA damages. Trace elements in the free salt forms have protective effect against cell toxicity induced by oxidative stress, metal-complex are more active in the attenuation of ROS particularly through superoxide dismutase mimetic activity. Manganese-complexes in protection of normal cell against radiation without any protective effect on cancer cells are more interesting compounds in this topic. The aim of this paper to review the role of trace elements in protection cells against genotoxicity and side effects induced by ionizing radiation.
Chemical Biology & Drug Design, 2016
Nanobodies are important biomolecules for tumor targeting. In this study, we synthesized and labe... more Nanobodies are important biomolecules for tumor targeting. In this study, we synthesized and labeled anti-epidermal growth factor receptor (EGFR) nanobody OA-cb6 with (99m) Tc(CO)3 (+) and evaluated its characteristics for targeting the EGFR in the A431 human epidermal carcinoma cell line. Nanobody radiolabeling was achieved with high yield and radiochemical purity, and the radioconjugate was stable. Biodistribution results in nude mice exhibited a favorable tumor-to-muscle ratio at 4 h post-injection, and tumor location was visualized at 4 h after injection of radiolabeled nanobody. Our result showed that the OA-cb6-(99m) Tc-tricarbonyl radiolabeled nanobody is a promising radiolabeled biomolecule for tumor imaging in cancers with high EGFR overexpression. This article is protected by copyright. All rights reserved.
Journal of Clinical Excellence, Mar 15, 2014
Acute pyelonephritis (APN) is the main predisposing factor for renal cortical scar (RCS) performi... more Acute pyelonephritis (APN) is the main predisposing factor for renal cortical scar (RCS) performing. Hypertension is a complication of RCS and appears in 10-20 Percent of patient in their life. Diagnosis and treatment of APN are necessary for prevention of RCS. The aim of this review is assessment of 99mTc-DMSA (99mTc-dimercaptosuccinic acid) scan value in diagnosis of APN and RCS and comparison of its results with other diagnostic methods such as radiology and ultrasonography. Ultrasonography (US) showed almost 39% of APN that diagnosed with 99mTC-DMSA scan. Computed Tomography Scan (CT scan) is a sensitive and effective method in diagnosis of APN and its complication. Spiral CT scan and Magnetic Resonance Imaging (MRI) are sensitive and relatively reliable tools in diagnosis of APN; however they are not practicable in the first evaluation and fallow up of infant and children with acute urinary tract infection. Power Doppler Ultrasonography (PDUS) demonstrated a sensitivity of 70 percent and a specificity of 85 percent in diagnosis of APN. 99m Tc-DMSA scan is the most sensitive diagnostic tool of APN and RCS with a sensitivity and specificity of 89-91 and 100 percent, respectively. Because 99m Tc-MAG3(99mTc-mercapto-acetylglycyl-glycyl-glycine)
Drug Discovery Today, 2007
Journal of Mazandaran University of Medical Sciences, Mar 15, 2014
Burn is an important life-threatening disturbance for human. The purpose of this study was review... more Burn is an important life-threatening disturbance for human. The purpose of this study was reviewing natural products recommended by resources of Iranian traditional medicine (ITM) for treatment of burn. We investigated the books of philosophers of Iranian traditional medicine; written sources from the 9 th century AD with the words of "Hergh" and "Fire burn" were studied. Bibliography of sources, name of products (plant, animal or mineral), using methods, and the nature of the products were recorded. More details of these natural products were evaluated in recent databases with focusing on burn treatment. 89 natural products to treat burns were presented in 11 traditional written sources. 46.1% of the products were in more than one source. 76.4% of the products were of herbal origin, 15.7% of mineral origin, and 7.9% were of animal origin. Most of the presented products had cold and dry nature. 18% of Materia have been described to have amazing effect or to be extremely beneficial. Some of reported products in the study are approved by the new standard and scientific methods; but most of the cases are not. This is a suitable issue for researchers that would like work on Iranian traditional medicine.
Cancer Biotherapy Radiopharmaceuticals, 2010
Radiopharmaceutical agents are utilized for imaging and treatment in nuclear medicine. Ionizing r... more Radiopharmaceutical agents are utilized for imaging and treatment in nuclear medicine. Ionizing radiation produces free radicals in the cell that can induce damage to the DNA and lead to side-effects and/or secondary tumors. Radioprotective agents are useful in eliminating or reducing the severity of deleterious cellular effects, which are caused by exposure to internal and/or external irradiation in patients or staff personnel. There are two strategies for the potential use of radioprotective agents in patients, including agents used in patients for selective protective effects, such as reducing mocusitis, myelotoxicity, and kidney damage induced by ionizing radiation in radioiodine and radiolabeled peptide therapy. Second, radioprotective agents can reduce chromosomal aberration induced by gamma- or beta-rays and reduce the risk of tumors in personnel and patients.
Journal of Ethnopharmacology, 2016
Burn injuries can cause detrimental long-term consequences and call for immediate management. Avi... more Burn injuries can cause detrimental long-term consequences and call for immediate management. Avicenna&amp;amp;amp;amp;amp;amp;amp;amp;#39;s Canon of Medicine, describing the use of Abu-Khalsa (Arnebia euchroma) (AE) as being effective for burn healing. The purpose of this study was to evaluate the healing effects of AE ointment (AEO) on patients with a second-degree burn wound and compare its results with silver sulfadiazine cream (SSD). In this prospective, single-blind clinical trial, 45 patients with similar types of second-degree burns at two different sites of the body were randomly assigned to the two treatment groups. One burn wound site of the patient was treated with SSD and another similar burn wound site with AEO once a day until complete healing was achieved. Wound size and percentage of wound healing were evaluated at 15 days. Satisfaction, clinical adverse events such as pain, burning, warming, erythema, edema, infection, inflammation, and general wound area were assessed on a visual analogue scales, and 6-point scales. The healing time was significantly shorter in the site treated with AEO than SSD (13.9 ± 5.3 vs. 17.5 ± 6.9 days, respectively). The severity of pain and burning were reduced in the AEO site compared with SSD site at the time of dressing change, while the warming score was significantly higher in the AEO wound area. Side-effects were lower in the site treated with AEO. In this clinical study, we demonstrated that AEO has benefits over SSD in the treatment of second-degree burn wounds and wound healing and is a viable medication for the management of second-degree burns.
Future Oncology, 2016
Cancer is one of the leading causes of mortality worldwide. Usually, the diagnosis of cancer at a... more Cancer is one of the leading causes of mortality worldwide. Usually, the diagnosis of cancer at an early stage is important to facilitate proper treatment and survival. Nuclear medicine has been successfully used in the diagnosis, staging, therapy and monitoring of cancers. Single-photon emission computed tomography and PET-based companion imaging agents are in development for use as a companion diagnostic tool for patients with ovarian cancer. The present review discusses the basic and clinical studies related to the use of radiopharmaceuticals in the diagnosis and management of ovarian cancer, focusing on their utility and comparing them with other imaging techniques such as computed tomography and MRI.
Journal of Clinical Excellence, Jan 15, 2013
Radiotherapy is widely used for cancer treatment. In radiotherapy, free radicals and other reacti... more Radiotherapy is widely used for cancer treatment. In radiotherapy, free radicals and other reactive oxygen species are produced when they are passed through cells. These free radicals can interact with critical macromolecules such as DNA which is led to cell toxicity and death.
Journal of Medical Sciences, 2006
The Mazandaran province is located in the Northern part of Iran. This province is surrounds by Al... more The Mazandaran province is located in the Northern part of Iran. This province is surrounds by Alborz mountain ranges and it is difficult to transfer patients to the high level of medical care in capital of Iran. Zare` hospital is only a &quot;Burn and Referral center&quot; in the North of Iran. The ...
Journal of Medical Sciences(Faisalabad), 2006
Archives of Oral Biology, 2015
The purpose of this study is to investigate the radioprotective effect of vitamin E as a natural ... more The purpose of this study is to investigate the radioprotective effect of vitamin E as a natural product. Vitamin E protects the salivary glands dysfunction that is induced by ionizing radiation. It was analysed with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Histopathological evaluation was performed. The rats were treated with vitamin E at dose of 400IU/kg 48, 24, and 1h before 15Gy gamma rays irradiation. The rats were evaluated for the salivary gland function through nuclear medicine protocol. Radiation causes significant salivary glands dysfunction at the 3rd and the 70th days with a reduction in radioactivity uptake in the salivary glands. Ratios of salivary gland to background radioactivities were 1.99±0.11, 1.58±0.08 and 1.92±0.04 for control, radiation, and vitamin E plus radiation groups, respectively. Vitamin E significantly improved salivary gland dysfunction induced by ionizing radiation in the rats. In conclusion, our results indicate protective effects of vitamin E against salivary gland dysfunction induced by gamma radiation. Thus, vitamin E is a promising radioprotective agent for patients who receive radiation in head and neck cancer therapy.
AbstractSince exposure to irradiation in radiotherapy or unwanted radiation, induces side effects... more AbstractSince exposure to irradiation in radiotherapy or unwanted radiation, induces side effects to health, it is important to makear effort to protect humans against side effects induced by irradiation. In these cases, radioprotective drugs could be used to reduce or delay the side effects and the mortality induced by irradiation. Although, thiol compounds were early compounds in these categories, administration of these agents have induced serious side effects and is limited to use clinically. The search for less-toxic radiation protectors has spurred interest in the development of natural products. Natural products have mainly antioxidant and immunostimulant activity. Cytokines and androsetendiol have immunomudulatory effects in the prevention of mortality induced by gamma irradiation in animal model. Many studies have showed herbal medicine has good radioprotective effects. Flavonoids are one of the main chemical compositions in herbal medicine with antioxidant activity. Althou...
Uploads
Papers by Seyed Jalal Hosseinimehr